Tizoxanide-d4 glucuronide_product_DataBase

Bioactivity	Tizoxanide-d4 glucuronide is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum[1].
Target	IC50: parasite
Invitro	Tizoxanide glucuronide (1-50 μg/ml; 46 hours) has effects on parasite development of Cryptosporidium parvum in HCT-8 cells. It exhibits MIC50 values of 2.2 μg/ml; 45.2 μg/ml; 11.7 μg/ml and 2.8 μg/ml in a sexual and sexual stages, sporozoite stage, asexual stages and sexual stages, respectively[1].
Name	Tizoxanide-d4 glucuronide
Formula	C16H11D4N3O10S
Molar Mass	445.39
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. G Gargala , et al. Efficacy of Nitazoxanide, Tizoxanide and Tizoxanide Glucuronide Against Cryptosporidium Parvum Development in Sporozoite-Infected HCT-8 Enterocytic Cells. J Antimicrob Chemother. 2000 Jul;46(1):57-60.

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