Thrombin inhibitor 6_product_DataBase

Bioactivity	Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant[1].
Invitro	Thrombin inhibitor 6 (compound 73) 在与 CD-1 小鼠和人微粒体孵育时是稳定的 (Clint (小鼠) = 60 μL/min/mg；Clint (人) = 17 μL/min/mg)[1].
In Vivo	Thrombin inhibitor 6 (compound 73) (9 mg/kg，静脉注射) 可延长 CD-1 小鼠的尾部出血时间[1]。Thrombin inhibitor 6 (compound 73) (5 mg/kg，口服) 在雄性 CD-1 小鼠中的 F(%) 为 22.8%，AUC 为 713.3 h.ng/mL，Cmax 为 127 ng/mL[1]。 Animal Model:
Name	Thrombin inhibitor 6
CAS	1628224-94-1
Formula	C18H19ClN4O2S
Molar Mass	390.89
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Short KM, et al. Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors. Eur J Med Chem. 2022 Oct 27;246:114855.

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