| Bioactivity | Amosulalol (YM 09538) is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR)[1]. |
| In Vivo | Amosulalol (3-30 mg/kg; 口服; 单剂量) 降低高血压大鼠的急性收缩压[1]。Amosulalol (50 mg/kg; 口服; 每天 2 次, 共 12 周) 产生不耐受的降压作用，还降低高血压大鼠模型中心率和血浆肾素活性 (PRA) 增加[1]。 |
| Name | Amosulalol |
| CAS | 85320-68-9 |
| Formula | C18H24N2O5S |
| Molar Mass | 380.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Honda K, et al. Autonomic and antihypertensive activity of oral amosulalol (YM-09538), a combined alpha- and beta-adrenoceptor blocking agent in conscious rats. Jpn J Pharmacol. 1985 May;38(1):31-41. |