| Bioactivity | ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with a Ki of 3.30 μM. ThioLox shows anti-inflammatory and neuroprotective properties[1]. | ||||||||||||
| Target | Ki: 3.30 μM (15-LOX-1) | ||||||||||||
| Invitro | ThioLox (50 μM; 24 h) 抑制精确切肺切片 (PCLS) 中白细胞介素 (IL-1β, IL-6, IL-8, IL-12b, TNFα 和 iNOS) 的表达[1]。ThioLox (10 μM; 16 h) 在神经元细胞中防止脂质过氧化和线粒体超氧化物的形成[1]。ThioLox (5-20 μM; 14-16 h) 保护 HT-22 细胞免受谷氨酸毒性，显著降低神经元细胞死亡[1]。 RT-PCR[1] Cell Line: | ||||||||||||
| In Vivo | ThioLox 的 logP 值为 3，测得的数值预测能透过血脑屏障[1]。 | ||||||||||||
| Name | ThioLox | ||||||||||||
| CAS | 1202193-89-2 | ||||||||||||
| Formula | C15H18N2OS | ||||||||||||
| Molar Mass | 274.38 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Eleftheriadis N, et al. Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties. Eur J Med Chem. 2016 Oct 21;122:786-801. |
ThioLox
CAS: 1202193-89-2 F: C15H18N2OS W: 274.38
ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with a Ki of 3.30 μM. ThioLox shows anti-inflammatory a
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