| Bioactivity | CB1/2 agonist 2 (compound 23) is a potent non-selective cannabinoid ligand, with Ki values of 3.5 and 1.2 nM, respectively. CB1/2 agonist 2 can behave as a full CB1 agonist and CB2 competitive inverse agonist. CB1/2 agonist 2 shows antinociceptive activity[1]. |
| Invitro | CB1/2 agonist 2 (compound 23) (1 µM, 24-72 h) exhibits a very low cytotoxic potential in Hep-G2 cells[1]. CB1/2 agonist 2 (0-10 µM) shows a slight but significant inhibition of [35S]GTPγS binding to hCB2-CHO cell membranes, with a mean EC50 of 397.90 nM and a mean Emax value of -17.81%[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| In Vivo | CB1/2 agonist 2 (compound 23) (0-6 mg/kg, IP, once) significantly reduces the late phase of formalin-induced nocifensive behaviour at 6 mg/kg[1]. Animal Model: |
| Name | CB1/2 agonist 2 |
| CAS | 2772379-97-0 |
| Formula | C26H43NO3 |
| Molar Mass | 417.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Brizzi A, et al. Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity. Bioorg Med Chem. 2020 Jun 1;28(11):115513. |
CB1/2 agonist 2
CAS: 2772379-97-0 F: C26H43NO3 W: 417.62
CB1/2 agonist 2 (compound 23) is a potent non-selective cannabinoid ligand, with Ki values of 3.5 and 1.2 nM, respective
Data collection：peptidedb@qq.com
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