Tetrindole mesylate_product_DataBase

Bioactivity	Tetrindole mesylate is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole mesylate inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole mesylate has antidepressant activity[1][2].
Invitro	Tetrindole mesylate 对 6 种人乳腺肿瘤细胞系 (MCF-7、HCC1954、T47D、MDA-MB-157、ZR75-1、BT474) 的 IC50 值为 0.51-1.37 μM[2]。
In Vivo	Tetrindole mesylate (25 mg/kg; 口服灌胃; 单剂量) 在体重 180-200 的雄性白化大鼠中，0.5-1 小时内抑制脑和肝脏线粒体 MAO A 80%，并且 24 小时后酶活性开始明显恢复 g[1]。
Name	Tetrindole mesylate
CAS	170964-68-8
Formula	C21H30N2O3S
Molar Mass	390.54
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. A E Medvedev, et al. Monoamine oxidase inhibition by novel antidepressant tetrindole. Biochem Pharmacol. 1994 Jan 20;47(2):303-8. [2]. William D Gwynne, et al. Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells. Cell Mol Biol Lett. 2019 Nov 12;24:59.

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