| Bioactivity | Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) trihydrochloride is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid trihydrochloride is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid trihydrochloride serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid[1]. |
| Invitro | Tetrahydrofolic acid (0 -200 μM；3 天；Adh5-/- DT40 细胞) trihydrochloride 暴露对 Adh5 和范可尼贫血 (FA) 缺陷细胞具有细胞毒性，产生广泛的 DNA 损伤和染色体累积中断[1]。 Tetrahydrofolic acid (0-100 μM；16 小时；Adh5-/- DT40 细胞) trihydrochloride 处理强烈促进 FANCD2 和 ser139-H2AX 聚焦在 Adh5-/- 细胞中以剂量依赖性方式形成[1]。 由于不受控制的活动，Tetrahydrofolic acid trihydrochloride 暴露会激活 DNA 损伤反应 (DDR) 胸苷酸合成酶的作用，导致必需核苷酸耗尽，并通过同源重组机制促进修复[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Tetrahydrofolic acid trihydrochloride 相关抗体: Cell Viability Assay[1] Cell Line: |
| In Vivo | Tetrahydrofolic acid (62.5 mg/kg；腹膜内注射；每天；Adh5-/- 小鼠) trihydrochloride 处理扰乱造血细胞的造血功能，增加 ser139-H2AX 磷酸化，并降低祖细胞 (HSPC) 的存活率表明过量的 Tetrahydrofolic acid trihydrochloride 可能对骨髓细胞具有致突变性和遗传毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 150731-85-4 |
| Formula | C19H26Cl3N7O6 |
| Molar Mass | 554.81 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Steven W. Bailey, et al. Synthesis of Tetrahydropteridine C6-Stereoisomers, Including N6-Formyl-(68)-tetrahydrofolic Acid. The Journal of Organic Chemistry, 57(16), 4470-4477. |
Tetrahydrofolic acid trihydrochloride
CAS: 150731-85-4 F: C19H26Cl3N7O6 W: 554.81
Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) trihydrochloride is the biologically active vitamin B9 folate deri
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.