Rp-8-pCPT-cGMPS sodium_product_DataBase

Bioactivity	Rp-8-pCPT-cGMPS sodium is the sodium salt form of Rp-8-pCPT-cGMPS. Rp-8-pCPT-cGMPS is an inhibitor for cGMP-dependent protein kinase (cGK). Rp-8-pCPT-cGMPS sodium is an agonist for cyclic nucleotide-gated (CNG) channels in a voltage-dependent manner[1][2].
In Vivo	Rp-8-pCPT-cGMPS sodium (5 nM，鞘内注射，每天一次，持续 3 天) 抑制 cGMP-cGKI 通路，抑制 Sprague-Dawley 大鼠模型中肿瘤细胞植入 (TCI) 诱导的热痛觉过敏和机械异常性疼痛[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	208445-07-2
Formula	C16H14ClN5NaO6PS2
Molar Mass	525.86
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Liu S, et al., cGMP and cGMP-dependent protein kinase I pathway in dorsal root ganglia contributes to bone cancer pain in rats. Spine (Phila Pa 1976). 2014 Sep 1;39(19):1533-41. [2]. Wei JY, et al., Substituted cGMP analogs can act as selective agonists of the rod photoreceptor cGMP-gated cation channel. J Mol Neurosci. 1998 Feb;10(1):53-64.

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