Teixobactin_product_DataBase

Bioactivity	Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III[1][2][3].
Invitro	Teixobactin (0-128 µg/mL) 显示出抗菌活性，对 MRSA ATCC 33591 的 MIC 值为 0.25 µg/mL[2]。Teixobactin (0-24 h) 显示出抗菌活性，对 Clostridium difficile, Bacillus anthracis 的 MIC 值分别为5、20 ng/mL[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Teixobactin 相关抗体:
In Vivo	Teixobactin (1-20 mg/kg; i.v.; once) 在小鼠体内表现出抗菌活性[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	1613225-53-8
Formula	C58H95N15O15
Molar Mass	1242.47
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Piddock LJ. Teixobactin, the first of a new class of antibiotics discovered by iChip technology? J Antimicrob Chemother. 2015 Oct;70(10):2679-80. [2]. Parmar A, et al. Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding. Chem Sci. 2017 Dec 1;8(12):8183-8192. [3]. Ling LL, et al. A new antibiotic kills pathogens without detectable resistance. Nature. 2015 Jan 22;517(7535):455-9.

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