| Bioactivity | AO-022 is a potent TALDO1 allosteric inhibitor. AO-022 decreases the expression of vimentin and snail. AO-022 shows antiproliferative activity and antitumor activity. AO-022 has the potential for the research of breast cancer[1]. |
| Target | TALDO1 |
| Invitro | AO-022 (5, 10, 20, 40, 80 µM; 24 h) 以剂量依赖性方式抑制 MDA-MB-231 细胞中的细胞活力[1]。AO-022 (0, 2.5,5, 10, 20 µM; 24 h) 以剂量依赖性方式降 vimentin 和 snail 的蛋白表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> AO-022 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | AO-022 (50 mg/kg; i.p.; every other day for fourteen days) 在小鼠体内显示出抗肿瘤活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C21H16ClNO4S |
| Molar Mass | 413.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xu G, Huang R, Wumaier R, Lyu J, Huang M, Zhang Y, Chen Q, Liu W, Tao M, Li J, Tao Z, Yu B, Xu E, Wang L, Yu G, Gires O, Zhou L, Zhu W, Ding C, Wang H. Proteomic Profiling of Serum Extracellular Vesicles Identifies Diagnostic Signatures and Therapeutic Targets in Breast Cancer. Cancer Res. 2024 Jun 20. |