| Bioactivity | Tau conotoxin CnVA is a small peptide found in the venom of the Conus consors pit viper, belonging to the T1 pit viper peptide superfamily. Tau conotoxin CnVA shows a highly selective interaction with the somatostatin sst3 receptor (Ki=1.5 µM) and is the only toxin known to interact with this subfamily of G protein-coupled receptors (GPCRs). Tau conotoxin CnVA can be used in the study of diseases associated with the sst3 receptor, such as pancreatic cancer or pituitary adenomas[1]. |
| CAS | 1436463-45-4 |
| Sequence | Glu-Cys-Cys-His-Arg-Gln-Leu-Leu-Cys-Cys-Leu-Arg-Phe-Val-NH2 (Disulfide bridge: Cys2-Cys9; Cys3-Cys10) |
| Shortening | ECCHRQLLCCLRFV-NH2 (Disulfide bridge: Cys2-Cys9; Cys3-Cys10) |
| Formula | C72H116N24O17S4 |
| Molar Mass | 1718.10 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Petrel C, et al. Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor[J]. Biochemical pharmacology, 2013, 85(11): 1663-1671. |
Tau conotoxin CnVA
CAS: 1436463-45-4 F: C72H116N24O17S4 W: 1718.10
Tau conotoxin CnVA is a small peptide found in the venom of the Conus consors pit viper, belonging to the T1 pit viper p
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