| Bioactivity | Cyclic L27-11 is a cyclic peptide-like antibiotic with strong antibacterial activity against specific bacteria such as Pseudomonas sp. Cyclic L27-11 shows nanomolar antibacterial activity against Pseudomonas sp., especially Pseudomonas aeruginosa. Cyclic L27-11 interferes with the function of bacterial outer membrane protein LptD, preventing the normal transport of lipopolysaccharide (LPS), leading to the accumulation of membrane-like substances in bacterial cells, which in turn affects the survival of bacteria. Cyclic L27-11 can be used in the development of antibacterial agents[1]. |
| CAS | 1221423-80-8 |
| Sequence | cyclo(Thr-Trp-Leu-Lys-Lys-Arg-Arg-Trp-Lys-Lys-Ala-Lys-{d-Pro}-Pro) |
| Shortening | cyclo(TWLKKRRWKKAK-{d-Pro}-P) |
| Formula | C87H141N27O15 |
| Molar Mass | 1805.22 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Schmidt J, et al. Structural studies of β-hairpin peptidomimetic antibiotics that target LptD in Pseudomonas sp[J]. Bioorganic & medicinal chemistry, 2013, 21(18): 5806-5810. |
Cyclic L27-11
CAS: 1221423-80-8 F: C87H141N27O15 W: 1805.22
Cyclic L27-11 is a cyclic peptide-like antibiotic with strong antibacterial activity against specific bacteria such as P
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