| Bioactivity | Tat-peptide 168-189 is a cell-permeable and Tat-labeled fusion peptide, corresponding to residues 168-189 of rat G3BP1. Tat sequence from HIV, is placed at the least conserved end of the sequence, for cell permeability. Tat-peptide 168-189 is the negtive control of Tat-peptide 190-208 (HY-P5118), as Tat-peptide 190-208 increases axon growth and increases the number of neurites per neuron[1]. |
| Invitro | Tat-peptide 190-208 (10 μM、20 μM;24 小时) 在分离的 DRG 培养物中增加轴突长度 10 μM,在 iMotor 神经元中增加 20 μM[1]。Tat-peptide 190-208 (10 μM;3 天) 增加从每个神经元延伸的轴突总数[1]。 |
| Name | Tat-peptide control 168-189 |
| Sequence | Asp-Asp-Ser-Gly-Thr-Phe-Tyr-Asp-Gln-Ala-Val-Val-Ser-Asn-Asp-Met-Glu-Glu-His-Leu-Glu-Glu-Pro-Tyr-Gly-Asn-Lys-Lys-Asn-Asn-Gln-Asn-Asn-Asn |
| Shortening | DDSGTFYDQAVVSNDMEEHLEEPYGNKKNNQNNN |
| Formula | C162H239N47O65S |
| Molar Mass | 3916.97 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sahoo PK, et al. Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration. |