| Bioactivity | Tat-peptide 190-208 TFA is a cell-permeable and Tat-labeled fusion peptide, corresponding to residues 190-208 of rat G3BP1. Tat sequence from HIV, is placed at the least conserved end of the sequence, for cell permeability. Tat-peptide 190-208 TFA increases axon growth and increases the number of neurites per neuron. Tat-peptide 190-208 TFA likely exhibits an axon intrinsic mechanism. Tat-peptide 190-208 TFA can be used for ischemic protection during endovascular repair for intracranial aneurysms[1]. | ||||||
| Invitro | Tat-peptide 190-208 TFA (10 μM、20 μM；24 小时) 在分离的 DRG 培养物中增加轴突长度 10 μM，在 iMotor 神经元中增加 20 μM[1]。Tat-peptide 190-208 TFA (10 μM；3 天) 增加从每个神经元延伸的轴突总数[1]。 | ||||||
| Name | Tat-peptide 190-208 TFA | ||||||
| Sequence | Tyr-Gly-Asn-Lys-Lys-Asn-Asn-Gln-Asn-Asn-Asn-Val-Ala-Glu-Pro-Glu-Pro-Asp-Pro-Glu-Pro-Glu-Pro-Glu-Gln-Glu-Pro-Val-Ser-Glu | ||||||
| Shortening | YGNKKNNQNNNVAEPEPDPEPEPEQEPVSE | ||||||
| Formula | C142H214N40O57.C2HF3O2 | ||||||
| Molar Mass | 3507.47 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
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| Reference | [1]. Sahoo PK, et al. Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration. |
Tat-peptide 190-208 TFA
CAS: F: C142H214N40O57.C2HF3O2 W: 3507.47
Tat-peptide 190-208 TFA is a cell-permeable and Tat-labeled fusion peptide, corresponding to residues 190-208 of rat G3B
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