| Bioactivity | Tat-NTS peptide is a cell-penetrating peptide with neuroprotective effects. Tat-NTS peptide can specifically inhibit the nuclear translocation of ANXA1 and reduce neuronal apoptosis in ischemic areas. Moreover, Tat-NTS peptide can reduce the volume of cerebral ischemic infarction and can be used in the research of ischemic stroke[1]. |
| Invitro | Tat-NTS peptide (20 μM) 在神经元细胞中能阻断 ANXA1 核迁移而不影响其他蛋白的核易位[1]。Tat-NTS peptide (20 μM) 能抑制 ANXA1 与 p53 的结合，减轻氧葡萄糖剥夺/再灌注 (OGD/R) 诱导的神经元凋亡，具有神经元细胞保护作用[1]。Tat-NTS peptide (20 μM) 可显著提高 OGD/R 后的神经元细胞的活力[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Tat-NTS peptide 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | Tat-NTS peptide (0.5-10 mg/kg; 侧脑室注射; 单剂量) 在大脑动脉闭塞 (MCAO) C57BL/6 小鼠中减少 ANXA1 与 importin β 的相互作用，并阻止 ANXA1 在体内的核易位。Tat-NTS peptide 减轻小鼠缺血损伤后神经元细胞凋亡，具有脑缺血的神经保护作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Sequence | Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Ser-Phe-Pro-His-Leu-Arg-Arg-Val-Phe-NH2 |
| Shortening | YGRKKRRQRRRRSFPHLRRVF-NH2 |
| Formula | C125H212N54O24 |
| Molar Mass | 2855.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li X, et al. A novel cell-penetrating peptide protects against neuron apoptosis after cerebral ischemia by inhibiting the nuclear translocation of annexin A1. Cell Death Differ. 2019 Jan;26(2):260-275. |