| Bioactivity | Tariquidar dimesylate (XR9576 dimesylate) is a P-glycoprotein (ABCB1) inhibitor. Tariquidar dimesylate increases the concentration of the drug in the brain by binding to ABCB1, preventing it from transporting the drug from inside to outside the brain. Tariquidar dimesylate can be used in the study of blood-brain barrier penetration and multidrug resistance[1]. |
| CAS | 625375-84-0 |
| Formula | C40H46N4O12S2 |
| Molar Mass | 838.94 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tournier N, et al. Complete inhibition of ABCB1 and ABCG2 at the blood–brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C] erlotinib[J]. Journal of Cerebral Blood Flow & Metabolism, 2021, 41(7): 1634-1646. |
Tariquidar dimesylate
CAS: 625375-84-0 F: C40H46N4O12S2 W: 838.94
Tariquidar dimesylate (XR9576 dimesylate) is a P-glycoprotein (ABCB1) inhibitor. Tariquidar dimesylate increases the con
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