| Bioactivity | LY2365109 is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a[1][2]. |
| In Vivo | LY2365109 (0.3-30 mg/kg; p.o.) 导致 Sprague-Dawley 大鼠脑脊液中甘氨酸水平出现剂量依赖性升高[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 868265-28-5 |
| Formula | C22H27NO5 |
| Molar Mass | 385.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54. [2]. Shen HY et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015 Dec;99:554-65. |