| Bioactivity | Taltobulin intermediate-4 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1]. | ||||||||||||
| Name | Taltobulin intermediate-4 | ||||||||||||
| CAS | 187345-37-5 | ||||||||||||
| Formula | C22H40N2O5 | ||||||||||||
| Molar Mass | 412.56 | ||||||||||||
| Appearance | 油状物 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45. |
Taltobulin intermediate-4
CAS: 187345-37-5 F: C22H40N2O5 W: 412.56
Taltobulin intermediate-4 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin com
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