| Bioactivity | TYA-018 is an orally active, potent and highly selective HDAC6 inhibitor. TYA-018 can protect heart function in mice. TYA-018 also enhances energetics in mice by increasing expression of targets associated with fatty acid metabolism, protein metabolism, and oxidative phosphorylation[1]. |
| In Vivo | TYA-018 (15 mg/kg，口服强饲法，每天，持续 8 周)可防止 BAG3cKO 小鼠中的肌节损伤，降低 Nppb 表达[1] 。 Animal Model: |
| Name | TYA-018 |
| CAS | 2653254-31-8 |
| Formula | C15H13ClF2N4O3S2 |
| Molar Mass | 434.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang J, et al. Phenotypic screening with deep learning identifies HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopathy. Sci Transl Med. 2022 Jul 6;14(652):eabl5654. |
TYA-018
CAS: 2653254-31-8 F: C15H13ClF2N4O3S2 W: 434.87
TYA-018 is an orally active, potent and highly selective HDAC6 inhibitor. TYA-018 can protect heart function in mice. TY
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.