| Bioactivity | TX2-120-1 possesses the ability to bind to Her3, with an IC50 value of 56 nM for Her3. TX2-120-1 can be used for the synthesis of TX2-121-1 (HY-118998)[1]. |
| Target | IC50: 56 nM (Her3). |
| In Vivo | TX2-120-1 (0.5-2 μM; 12 h) 由于没有疏水金刚烷基团，所以在 PC9 GR4 细胞中诱导 Her3 降解或阻断 Her3 依赖性信号传导方面效果较差[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 1603845-45-9 |
| Formula | C26H27N7O2 |
| Molar Mass | 469.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lim S M, et al. Development of small molecules targeting the pseudokinase Her3[J]. Bioorganic & medicinal chemistry letters, 2015, 25(16): 3382-3389. |
TX2-120-1
CAS: 1603845-45-9 F: C26H27N7O2 W: 469.54
TX2-120-1 possesses the ability to bind to Her3, with an IC50 value of 56 nM for Her3. TX2-120-1 can be used for the syn
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