| Bioactivity | TWIK-1/TREK-1-IN-1 (compound 2a) is an inhibitor of the TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.36 μM and 14.6 μM, respectively, and has antidepressant-like effects[1]. |
| Target | IC50: 9.36 μM (TREK-1/TREK-1), 14.6 μM (TWIK-1/TREK-1) |
| Name | TWIK-1/TREK-1-IN-1 |
| CAS | 1440532-30-8 |
| Formula | C21H24F3NO3 |
| Molar Mass | 395.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lee EH, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Sep;165:115139.. . |
TWIK-1/TREK-1-IN-1
CAS: 1440532-30-8 F: C21H24F3NO3 W: 395.42
TWIK-1/TREK-1-IN-1 (compound 2a) is an inhibitor of the TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-
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