TUG-905_product_DataBase

Bioactivity	TUG-905 is a potent GPR40 agonist with an pEC50 value of 7.03. TUG-905 increases hypothalamic cell proliferation and survival. TUG-905 reduces body mass and increases the POMC mRNA expression[1][2].
Target	pEC50: 7.03 (GPR40)
Invitro	TUG-905 (10 µM；7、13 天) 促进细胞增殖和增加神经母细胞标记物 DCX mRNA 水平[2]。TUG-905 (10 µM；2、4、24 小时) 增加 Neuro2a (鼠神经母细胞瘤) 细胞中的 GPR40、BDNF 基因表达[2]。 Western Blot Analysis[2] Cell Line:
In Vivo	TUG-905 (2.0 μL，1.0 mM；i.c.v.；每天两次，持续 6 天) 可降低体重并表现出减少热量摄入的趋势[1]。 Animal Model:
Name	TUG-905
CAS	1390641-90-3
Formula	C27H30FNO5S
Molar Mass	499.59
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Dragano NRV, et al. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation. J Neuroinflammation. 2017 Apr 26;14(1):91. [2]. Engel DF, et al. Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms. Sci Rep. 2020 Jul 6;10(1):11047.

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