TSPO Ligand-Linker Conjugates 1_product_DataBase

Bioactivity	TSPO Ligand-Linker Conjugates 1 contains a ligand for translocator protein (TSPO) and a linker, which is used for the synthesis of mitochondria-targeting autophagy-targeting chimera (AUTAC). AUTAC can bind the TSPO on the outer mitochondrial membrane (OMM) of mitochondria and degrades impaired mitochondria and proteins via mitophagy, and improves mitochondrial activity. TSPO Ligand-Linker Conjugates 1 can be used in mitochondrial dysfunction related research, including neurodegenerative diseases, cancer, and diabetes[1].
Invitro	AUTAC (0-100 μM, 24 h) realizes targeted degradation of endogenous proteins in HeLa cells (MetAP2, FKBP12)[1].AUTAC (10 μM, 10 h) reverses mitochondrial dysfunction via K63-Linked ubiquitination in HeLa cells[1]. Western Blot Analysis[1] Cell Line:
Name	TSPO Ligand-Linker Conjugates 1
Formula	C32H55N3O10S
Molar Mass	673.86
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Daiki Takahashi, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.

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