TRPV4 antagonist 4_product_DataBase

Bioactivity	TRPV4 antagonist 4 is a potent TRPV4 antagonist with an IC50 value of 22.65 nM. TRPV4 antagonist 4 inhibits TRPV4 current. TRPV4 antagonist 4 shows protective effects on acute lung injury[1].
Invitro	TRPV4 antagonist 4 (compound 2b; 1 µM) 抑制 TRPV4-CHO 细胞中 GSK1016790A (HY-19608) (100 nM) 诱导的 TRPV4 全细胞电流[1]。TRPV4 antagonist 4 抑制 HUVEC 中对 LPS (HY-D1056) 诱导的通透性反应[1]。
In Vivo	TRPV4 antagonist 4 (1 mg/kg; i.p.) 在 LPS 诱导的小鼠肺损伤模式中改善肺水肿和相关肺病理变化[1]。 Animal Model:
Name	TRPV4 antagonist 4
CAS	2918803-89-9
Formula	C28H32Cl2N6O
Molar Mass	539.50
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ai C, et al. Discovery and pharmacological characterization of a novel benzimidazole TRPV4 antagonist with cyanocyclobutyl moiety. Eur J Med Chem. 2023 Mar 5;249:115137.

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