| Bioactivity | JNK3 inhibitor-8 is a potent, delective, orally active and cross the blood-brain barrier JNK3 inhibitor with IC50 values of 21, 2203, >10000 nM for JNK3, JNK2, JNK1, respectively. JNK3 inhibitor-8 shows significant neuroprotective effects. JNK3 inhibitor-8 has the potential for the research of Alzheimer’s disease (AD)[1]. |
| Invitro | JNK3 inhibitor-8 (compound 3h; 10, 20 µM; 24, 48 h) 增加用 10 μM amyloid-β1-42处理的原代大鼠皮层神经元细胞活力[1]。JNK3 inhibitor-8 (10, 20 µM) 降低 p-c-jun (S63)、p-c-jun (S73)、PARP 和 p-Tau 的表达当用10 μM 的 amyloid-β1-42 处理时[1]. Cell Viability Assay[1] Cell Line: |
| In Vivo | JNK3 inhibitor-8 (30、60 mg/kg；口服；每日一次，持续 4 周) 对小鼠显示出显着的神经保护作用[1]。 Animal Model: |
| Name | JNK3 inhibitor-8 |
| Formula | C32H30FN7O3 |
| Molar Mass | 579.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jun J, et al. Carbamate JNK3 Inhibitors Show Promise as Effective Treatments for Alzheimer's Disease: In Vivo Studies on Mouse Models. J Med Chem. 2023 Apr 24. |