| Bioactivity | TRPV1-Tat is an antagonistic peptide that fuses the TRPV1 (transient receptor potential vanilla subtype 1) of the cell-penetrating peptide Tat. TRPV1-Tat blocks this phosphorylation process by competitively binding to the AKAP79 binding site of TRPV1, thereby inhibiting the sensitization of TRPV1. TRPV1-Tat can be used in the study of inflammatory pain[1]. |
| Sequence | Lys-Asp-Asp-Tyr-Arg-Trp-Cys-Phe-Arg-Val-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg |
| Shortening | KDDYRWCFRVYGRKKRRQRRR |
| Formula | C127H206N50O29S |
| Molar Mass | 2929.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fischer M J M, et al. Disrupting sensitization of transient receptor potential vanilloid subtype 1 inhibits inflammatory hyperalgesia[J]. Journal of Neuroscience, 2013, 33(17): 7407-7414. |