| Bioactivity | TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4[1]. | ||||||
| Invitro | TRAP-6 (0.01-10 μM) triggers calcium mobilization in Xenopus oocytes heterologously expressing PAR1[1].TRAP-6 (0.01-10 μM; 30 min) activates human platelets[1].TRAP-6 (100 μM) does not cause the platelets of rabbits or rats to change shape, aggregate, release granule contents, or form thromboxane[2]. | ||||||
| Name | TRAP-6 | ||||||
| CAS | 141136-83-6 | ||||||
| Sequence | Ser-Phe-Leu-Leu-Arg-Asn | ||||||
| Shortening | SFLLRN | ||||||
| Formula | C34H56N10O9 | ||||||
| Molar Mass | 748.87 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |