| Bioactivity | Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly[1][2]. | ||||||
| Invitro | Octreotide reverses the PA-induced alterations in Akt and GSK3β phosphorylation and expression of GS mRNA in HepG2 cells[1].Octreotide (10‑8mM, 6 hours) induces phosphorylated‑glycogen synthase kinase 3β (GSK3β) phosphorylation and increases glycogen synthase (GS) activity[3]. Western Blot Analysis[3] Cell Line: | ||||||
| Name | Octreotide | ||||||
| CAS | 83150-76-9 | ||||||
| Sequence | Phe-Cys-Phe-Trp-Lys-Thr-Cys-Thr (Disulfide bridge: Cys2-Cys7) | ||||||
| Shortening | FCFWKTCT (Disulfide bridge: Cys2-Cys7) | ||||||
| Formula | C49H66N10O10S2 | ||||||
| Molar Mass | 1019.24 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*该产品在溶液状态不稳定，建议您现用现配，即刻使用。 |
Octreotide
CAS: 83150-76-9 F: C49H66N10O10S2 W: 1019.24
Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue.
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