| Bioactivity | TR-100 is a small molecule inhibitor of tumor-associated troponin (Tpm). TR-100 affects the interaction of Tpm3.1 with actin filaments by binding to the C-terminal of Tpm3.1, thereby affecting the stability and function of the actin filaments. This mechanism of action allows TR-100 to specifically affect actin filaments in cancer cells without compromising heart muscle function. TR-100 can be used to study the role of Tpm3.1 in cancer cell proliferation and survival and the effects of Tpm3.1 on insulin-stimulated glucose uptake and insulin secretion[1][2]. |
| CAS | 1128165-86-5 |
| Formula | C26H38N4O |
| Molar Mass | 422.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hill T A, et al. Inhibition of Dynamin Mediated Endocytosis by the Dynoles--Synthesis and Functional Activity of a Family of Indoles[J]. Journal of medicinal chemistry, 2009, 52(12): 3762-3773. [2]. Kee A J, et al. On-target action of anti-tropomyosin drugs regulates glucose metabolism[J]. Scientific reports, 2018, 8(1): 4604. |