| Bioactivity | TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM[1]. | ||||||||||||
| Name | TP0463518 | ||||||||||||
| CAS | 1558021-37-6 | ||||||||||||
| Formula | C20H18ClN3O6 | ||||||||||||
| Molar Mass | 431.83 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Kato S, et al. TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation. Eur J Pharmacol. 2018 Nov 5;838:138-144. |
TP0463518
CAS: 1558021-37-6 F: C20H18ClN3O6 W: 431.83
TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.