| Bioactivity | TMX1 is a BRD4 covalent molecular glue degrader. TMX1 is also a redox-sensitive oxidoreductase, enriched on the mitochondria-associated membrane (MAM), the site of ER-mitochondria Ca(2+) flux. TMX1 is a thiol-based tumor suppressor. TMX1 also increases mitochondrial ATP production and apoptosis progression[1][2]. |
| Name | TMX1 |
| Formula | C26H28N4O3S |
| Molar Mass | 476.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Raturi A, et al. TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux. J Cell Biol. 2016 Aug 15;214(4):433-44. [2]. Li Y D, et al. Template-assisted covalent modification of DCAF16 enables BRD4 molecular glue degraders[J]. Cancer Research, 2023, 83(7_Supplement): 3424-3424. |