| Bioactivity | TMI-1 is a potent inhibitor of disintegrin metalloenzyme 17 (ADAM17) and other MMPs. TMI-1 inhibits LPS-induced TNF-α secretion in human primary monocytes, and human whole blood[1]. TMI-1 selectively induces caspase-dependent apoptosis in triple negative (TN) and ERBB2-overexpressing breast tumor cell lines[2]. | |||||||||
| Name | TMI-1 | |||||||||
| CAS | 287403-39-8 | |||||||||
| Formula | C17H22N2O5S2 | |||||||||
| Molar Mass | 398.50 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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