| Bioactivity | TLR9-IN-1 is a potent and selective TLR9 inhibitor with an IC50 value of 7 nM for human TLR9. TLR9-IN-1 can be used for researching diseases associated with undesirable immune response[1]. |
| Invitro | TLR9-IN-1 (compound no.29) (0-10 μM; 24 h) exhibits moderately inhibitory activity against IL-1b with an IC50 of 1.61 μM in human monocytes (co-incubated with TLR8 agonist ORN8L, RNA oligonucleotide)[1]. |
| Name | TLR9-IN-1 |
| CAS | 2226366-86-3 |
| Formula | C23H31N7O |
| Molar Mass | 421.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Albert Frederick Candia, et al. Toll-like receptor antagonist compounds and methods of use. WO2018089695 |