| Bioactivity | TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM[1]. | ||||||||||||
| Target | IC50: 95 nM (Leukotriene C4 synthase) | ||||||||||||
| Invitro | TK05 reduces LTC4 production in a dose-dependent manner with an IC50 value of 318 ± 60 nM in MM6 Cells[1]. | ||||||||||||
| In Vivo | TK05 (0.12-6 mg/kg; given i.p.; only once) significantly reduces LTE4 levels[1]. Animal Model: | ||||||||||||
| Name | TK05 | ||||||||||||
| CAS | 1245734-61-5 | ||||||||||||
| Formula | C31H25ClN2O5 | ||||||||||||
| Molar Mass | 540.99 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Kleinschmidt TK, et al. Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase. J Pharmacol Exp Ther. 2015 Oct;355(1):108-16. |