| Bioactivity | PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1]. | ||||||||||||
| In Vivo | Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1]. | ||||||||||||
| Name | PF-04745637 | ||||||||||||
| CAS | 1917294-46-2 | ||||||||||||
| Formula | C27H32ClF3N2O2 | ||||||||||||
| Molar Mass | 509.00 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Laurie B. Schenkel, et al. The discovery of a potent series of carboxamide TRPA1 antagonists. J. Med. Chem. 2016, 59, 6, 2794-2809. |