| Bioactivity | TK-642 is a highly active, selective, orally bioavailable variant SHP2 inhibitor based on pyrazole and pyrazine (IC50=2.7 nmol/L). TK-642 can effectively inhibit the proliferation of esophageal carcinoma cells (KYSE-520 cells, IC50=5.73 mmol/L) and induce cell apoptosis. TK-642 can be used in the study of esophageal cancer[1]. |
| CAS | 2765183-10-4 |
| Formula | C17H20ClN7S |
| Molar Mass | 389.91 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tang K, et al. Discovery of TK-642 as a highly potent, selective, orally bioavailable pyrazolopyrazine-based allosteric SHP2 inhibitor[J]. Acta Pharmaceutica Sinica B, 2024. |