| Bioactivity | TJ08, a 1,2,5-trisubstituted benzimidazole derivative, efficiently induces G1/S phase arrest and promotes apoptosis in various cancer cells. TJ08 is an anticancer agent[1]. |
| Invitro | TJ08 (0-20 μM; 48 和 72 小时) 对多种癌细胞系具有抗增殖作用，IC50 范围为 1.88-3.82 μM[1]。 TJ08 (1-10 μM; 24 小时) 通过改变线粒体膜电位引发细胞凋亡[1]。 TJ08 (1-10 μM; 24 小时) 引发 S 期阻滞并阻止癌细胞进展[1]。 TJ08 (1-10 μM; 24 小时) 引起裂解半胱天冬酶的上调和抗凋亡 BCl2 蛋白的下调[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | TJ08 |
| Formula | C22H16FN3O4 |
| Molar Mass | 405.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |