| Bioactivity | TIM-098a is a selective AAK1 inhibitor with an IC50 of 0.24 µM. TIM-098a has no inhibitory activity against CaMKK isoforms. TIM-098a inhibits AAK1-regulated endocytosis by suppressing AAK1 kinase activity[1]. |
| Invitro | TIM-098a 可抑制转染培养细胞中的 AAK1 活性 (IC50=0.87 µM)[1]。TIM-098a (0.26、0.82、2.6、26 μM；6 小时) 在 AAK1/GST-AP2μ2 (145-162) 表达中以浓度依赖性方式抑制 AAK1 催化的 GST-AP2μ2 (145-162) Thr156 磷酸化 COS-7细[1]。TIM-098a (10 μM；6 小时) 将 AAK1 转染细胞中的早期内体数量恢复至未转染野生型细胞的水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> TIM-098a 相关抗体: |
| Formula | C18H11N3O2 |
| Molar Mass | 301.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Akari Yoshida, et al. Development of a novel AAK1 inhibitor via Kinobeads-based screening. Sci Rep. 2024 Mar 20;14(1):6723. |