| Bioactivity | MCTR3 is a potent cytokine of pro-resolving mediating maresin conjugates in tissue regeneration (MCTR), which reduces the inflammatory response and promotes the tissue regeneration. MCTR3 exhibits potency in ameliorating LPS-induced acute lung injury and arthritis[1][2][3]. |
| Invitro | MCTR3 (1 nM) 可通过 ALX/PINK1 通路缓解 MLE12 细胞中 LPS 诱导的细胞损伤和氧化应激，减少细胞凋亡 (apoptosis) 和自噬 (autophagy) 相关蛋白的产生[1]。MCTR3 (1 nM) 增强渗出白细胞的胞吞作用和细菌吞噬作用，减少中性粒细胞浸润和类二十烷酸水平[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MCTR3 相关抗体: Immunofluorescence[1] Cell Line: |
| In Vivo | MCTR3 (2 ng/g，腹腔注射，单剂量) 可缓解 C57BL/6 小鼠中 LPS 诱导的急性肺损伤，改善炎症和氧化反应，并减少细胞凋亡 (apoptosis)[1]。MCTR3 (1-100 nM，在冷水中) 以剂量依赖的方式刺激手术损伤的涡虫组织再生，50% 组织再生 (TRI50) 需要 2.5 天[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 1784701-63-8 |
| Formula | C25H37NO5S |
| Molar Mass | 463.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhuang R, et al., MCTR3 reduces LPS-induced acute lung injury in mice via the ALX/PINK1 signaling pathway. Int Immunopharmacol. 2021 Jan;90:107142. [2]. Dalli J et al., Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3. PLoS One. 2016 Feb 16;11(2):e0149319. [3]. Pistorius K, et al., MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis. EBioMedicine. 2022 May;79:103974. |