| Bioactivity | TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. | ||||||
| Invitro | PAR1 agonists stimulate concentration-dependent increases in [Ca2+]i and in the proportions of neurones. The maximal increase in [Ca2+]i above basal is detected in response to 10 μm TF-NH2 (peak 196.5±20.4 nM, n=25) when 50–80% of identified neurones responded[1]. SW620 cells cultured in the supernatant of TFLLR-NH2-activated platelets upregulate E-cadherin expression and downregulate the vimentin expression. In the in vitro platelet culture system, a TFLLR-NH2 dose-dependent increase of secreted TGF-β1 is detected in the supernatant[2]. | ||||||
| Name | TFLLR-NH2(TFA) | ||||||
| CAS | 1313730-19-6 | ||||||
| Shortening | TFLLR-NH2 | ||||||
| Formula | C33H54F3N9O8 | ||||||
| Molar Mass | 761.83 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |