| Bioactivity | Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis[1][2][3]. | ||||||
| Invitro | Plecanatide (1 nM-10 μM) activates GC-C receptor to stimulate cyclic guanosine monophosphate (cGMP) synthesis in a dose-dependent manner with EC50 of 190 nM in T84 cells[1]. | ||||||
| Name | Plecanatide | ||||||
| CAS | 467426-54-6 | ||||||
| Shortening | NDECELCVNVACTGCL (Disulfide bridge: Cys4-Cys12; Cys7-Cys15) | ||||||
| Formula | C65H104N18O26S4 | ||||||
| Molar Mass | 1681.89 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Plecanatide
CAS: 467426-54-6 F: C65H104N18O26S4 W: 1681.89
Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide ac
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