| Bioactivity | TF-S14 is a reverse agonist of RORγt (retinoic acid receptor-associated orphan receptor γt). TF-S14 reduces Th17 cell-associated cytokine production, including IL-17A, IL-21, and IL-22 by binding to and inhibiting RORγt activity. TF-S14 can be used in the study of autoimmune diseases and rejection in allotransplantation[1]. |
| CAS | 2425563-60-4 |
| Formula | C22H27N3O2S |
| Molar Mass | 397.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fouda A, et al. RORγt inverse agonist TF-S14 inhibits Th17 cytokines and prolongs skin allograft survival in sensitized mice[J]. Communications Biology, 2024, 7(1): 454. |