| Bioactivity | SQA1, a squaramide (SQA) derivative, is a CCR6 antagonist with a Kd of 250 nM. SQA1 is also a CXCR2 inhibitor. The intracellular pocket occupied by SQA1 overlaps with the G protein binding site and stabilizes the closed conformation of the intracellular pocket[1]. |
| CAS | 1255915-27-5 |
| Formula | C22H26N4O5 |
| Molar Mass | 426.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. David Jonathan Wasilko, et al. Structural basis for CCR6 modulation by allosteric antagonists. bioRxiv. April 06, 2024 |
SQA1
CAS: 1255915-27-5 F: C22H26N4O5 W: 426.47
SQA1, a squaramide (SQA) derivative, is a CCR6 antagonist with a Kd of 250 nM. SQA1 is also a CXCR2 inhibitor. The intra
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