| Bioactivity | TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration[1]. | ||||||||||||
| Target | Lats kinase. | ||||||||||||
| Invitro | TDI-011536 (3 µM; 24 h) reduces Yap phosphorylation and (3 µM; 5 days) induces proliferation of Müller glia in human retinal organoids[1]. Cell Proliferation Assay[1] Cell Line: | ||||||||||||
| In Vivo | TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs[1].TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes[1]. Animal Model: | ||||||||||||
| Name | TDI-011536 | ||||||||||||
| CAS | 2687970-96-1 | ||||||||||||
| Formula | C19H16N4O2S | ||||||||||||
| Molar Mass | 364.42 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Kastan NR, et al. Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2206113119. |
TDI-011536
CAS: 2687970-96-1 F: C19H16N4O2S W: 364.42
TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.