| Bioactivity | ML365 is a selective two-pore domain potassium channel KCNK3/TASK1 inhibitor, with an IC50 of 4 nM. ML365 acts as a pharmacological tool that can be used to examine the specific roles of TASK1 channels[1]. | ||||||||||||
| Target | IC50: 4 nM (TASK1/KCNK3), 390 nM (TASK3/KCNK9) | ||||||||||||
| Invitro | ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC50 = 4 nM) and an automated electrophysiology assay (IC50 = 16 nM)[1].ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG)[1].ML365 does not exhibit acute toxicity in cell-based assays at concentrations up to 30 μM[1]. | ||||||||||||
| Name | ML365 | ||||||||||||
| CAS | 947914-18-3 | ||||||||||||
| Formula | C22H20N2O3 | ||||||||||||
| Molar Mass | 360.41 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Zou B, et al. ML365: Development of Bis-Amides as Selective Inhibitors of the KCNK3/TASK1 Two Pore Potassium Channel. Probe Reports from the NIH Molecular Libraries Program [Internet]. |