Bioactivity | TAT-P110, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1[1]. |
Invitro | TAT-P110 完全阻止了 LPS 引起的线粒体融合细胞数量的下降;具有融合线粒体的细胞比例分别为:37%(LPS + P110)、36% (LPS + SC9)和 38% (无 LPS)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> TAT-P110 相关抗体: |
Sequence | Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Asp-Leu-Leu-Pro-Arg-Gly-Ser |
Shortening | YGRKKRRQRRRGGDLLPRGS |
Formula | C100H178N44O26 |
Molar Mass | 2412.76 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Luis Rios, et al. Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction. Nat Commun. 2023 Jul 19;14(1):4356. |