TAT-MEK1_product_DataBase

Bioactivity	TAT-MEK1 is an inhibitor ofERK2, consisting of TAT and MEK1 (N-terminal), TAT (YGRKKRRQRRR) derived from human immunodeficiency (HIV-1) transcriptional trans activator (TAT), is a cell-penetrating peptide. TAT-MEK1 IC50 in vitro for ERK2 is 29 μM[1][2].
Invitro	TAT-MEK1 (100 μM, 30 min) 在NIH.3T3和PC12细胞中能有效抑制荧光素酶的活性，对 ERK2 激活有抑制作用[2]。 0 --> TAT-MEK1 相关抗体: Western Blot Analysis[2] Cell Line:
Name	TAT-MEK1
CAS	566872-16-0
Sequence	Gly-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH2
Shortening	GYGRKKRRQRRRGMPKKKPTPIQLNP-NH2
Formula	C136H241N53O31S
Molar Mass	3146.77
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Lukanowska M, et al. Bioportides: bioactive cell-penetrating peptides that modulate cellular dynamics. Biotechnol J. 2013 Aug;8(8):918-30. [2]. Kelemen BR, et al. Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides. J Biol Chem. 2002 Mar 8;277(10):8741-8.

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