| Bioactivity | TAT-D1 peptide is a selective D1-D2 heterogeneous antagonist. TAT-D1 peptide destroys the heterodimer of the D1-D2 receptor by interacting with the specific domain of the D2 receptor through its unique amino acid sequence, in particular the two glutamate residues at the C terminal of the D1 receptor. TAT-D1 peptide can be used to study the role of D1-D2 receptor heterodimers in the regulation of depressive and anxiety-like behaviors[1]. |
| Sequence | Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Gln-Gly-Ser-Ser-Glu-Asp-Leu-Lys-Lys-Glu-Glu-Ala-Ala-Gly-Ile-Ala-Arg-Pro-Leu |
| Shortening | GRKKRRQRRRPQGSSEDLKKEEAAGIARPL |
| Formula | C144H257N57O43 |
| Molar Mass | 3474.94 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shen M Y F, et al. Rapid anti-depressant and anxiolytic actions following dopamine D1–D2 receptor heteromer inactivation[J]. European Neuropsychopharmacology, 2015, 25(12): 2437-2448. |