| Bioactivity | TAT-BH4 (Bcl-xL) localized mainly at the mitochondria, prevents apoptotic cell death. TAT-BH4 (Bcl-xL) contains the N-terminal eosin-labeled cysteine plus the protein transduction domain of HIV TAT protein (amino acids 49 to 57) fused to the Bcl-xL BH4 peptide. TAT-BH4 can be used for research of diseases caused by accelerated apoptosis[1]. |
| Name | TAT-BH4 (Bcl-xL) |
| Sequence | Ac-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-{βAla}-Ser-Asn-Arg-Glu-Leu-Val-Val-Asp-Phe-Leu-Ser-Tyr-Lys-Ser-Gln-Lys-Gly-Tyr-Ser |
| Shortening | Ac-GRKKRRQRRR-{βAla}-SNRELVVDFLSYKSQKGYS |
| Formula | C159H268N58O45 |
| Molar Mass | 3712.19 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shimizu S, et al. BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3100-5. |
TAT-BH4 (Bcl-xL)
CAS: F: C159H268N58O45 W: 3712.19
TAT-BH4 (Bcl-xL) localized mainly at the mitochondria, prevents apoptotic cell death. TAT-BH4 (Bcl-xL) contains the N-te
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