| Bioactivity | TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins[1]. TAPI-1 is also a metalloproteinase (MMP) inhibitor[2]. | ||||||||||||
| Target | TACE (ADAM17), MMP | ||||||||||||
| Invitro | TAPI-1 (1 µM for 30 min) increases cell viability in LPS-treated HK-2 cells[1].TAPI-1 attenuates oxidative stress and inflammatory cytokines[1]LPS treatment significantly induces renal IL-6 and TNFα mRNA expression, while these changes is attenuated with TAPI-1 pretreatment in LPS-treated HK-2 cells[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | TAPI-1 | ||||||||||||
| CAS | 163847-77-6 | ||||||||||||
| Formula | C26H37N5O5 | ||||||||||||
| Molar Mass | 499.60 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Bae EH, et al. Tumor necrosis factor α-converting enzyme inhibitor attenuates lipopolysaccharide-induced reactive oxygen species and mitogen-activated protein kinase expression in human renal proximal tubule epithelial cells. Korean J Physiol Pharmacol. 2 [2]. Moss ML, et al. Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation. Mediators Inflamm. 2017;2017:9673537. |
TAPI-1
CAS: 163847-77-6 F: C26H37N5O5 W: 499.60
TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metallopr
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